UVA irradiation strengthened an interaction between UBF1/2 proteins and H4K20 di-/tri-methylation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F19%3A00504509" target="_blank" >RIV/68081707:_____/19:00504509 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs10577-018-9596-x" target="_blank" >https://link.springer.com/article/10.1007%2Fs10577-018-9596-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10577-018-9596-x" target="_blank" >10.1007/s10577-018-9596-x</a>
Alternative languages
Result language
angličtina
Original language name
UVA irradiation strengthened an interaction between UBF1/2 proteins and H4K20 di-/tri-methylation
Original language description
Repair of ribosomal DNA (rDNA) is a very important nuclear process due to the most active transcription of ribosomal genes. Proper repair of rDNA is required for physiological biogenesis of ribosomes. Here, we analyzed the epigenetics of the DNA damage response in a nucleolar compartment, thus in the ribosomal genes studied in nonirradiated and UVA-irradiated mouse embryonic fibroblasts (MEFs). We found that the promoter of ribosomal genes is not abundant on H4K20me2, but it is densely occupied by H4K20me3. Ribosomal genes, regulated via UBF1/2 proteins, were characterized by an interaction between UBF1/2 and H4K20me2/me3. This interaction was strengthened by UVA irradiation that additionally causes a focal accumulation of H4K20me3 in the nucleolus. No interaction has been found between UBF1/2 and H3K9me3. Interestingly, UVA irradiation decreases the levels of H3K9me3 and H4K20me3 at 28S rDNA. Altogether, the UVA light affects the epigenetic status of ribosomal genes at 28S rDNA and strengthens an interaction between UBF1/2 proteins and H4K20me2/me3.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA18-07384S" target="_blank" >GA18-07384S: From conformation to biological functions of HP1 protein</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chromosome Research
ISSN
0967-3849
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
15
Pages from-to
41-55
UT code for WoS article
000460114900005
EID of the result in the Scopus database
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