How the molecular weight affects the in vivo fate of exogenous hyaluronan delivered intravenously: A stable-isotope labelling strategy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F21%3A00542790" target="_blank" >RIV/68081707:_____/21:00542790 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/21:00075076 RIV/61989592:15310/21:73609606 RIV/00216224:14310/21:00121603
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0144861721003143?token=3B1E30F1EFFA8B688701DCC15BDDC999A5E187E791E15A519C7A4D380A7A798486099FF4C0AB22482C63D972D480C238&originRegion=eu-west-1&originCreation=20210528071650" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0144861721003143?token=3B1E30F1EFFA8B688701DCC15BDDC999A5E187E791E15A519C7A4D380A7A798486099FF4C0AB22482C63D972D480C238&originRegion=eu-west-1&originCreation=20210528071650</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2021.117927" target="_blank" >10.1016/j.carbpol.2021.117927</a>

Result language
angličtina
Original language name
How the molecular weight affects the in vivo fate of exogenous hyaluronan delivered intravenously: A stable-isotope labelling strategy
Original language description
There is inconsistent information regarding the size effects of exogenously given hyaluronan on its in vivo fate. The data are often biased by the poor quality of hyaluronan and non-ideal labelling strategies used for resolving exogenous/endogenous hyaluronan, which only monitor the label and not hyaluronan itself. To overcome these drawbacks and establish the pharmacokinetics of intravenous hyaluronan in relation to its Mw, 13C-labelled HA of five Mws from 13.6?1562 kDa was prepared and administered to mice at doses 25-50 mg kg?1. The elimination efficiency increased with decreasing Mw. Low Mw hyaluronan was rapidly eliminated as small hyaluronan fragments in urine, while high Mw hyaluronan exhibited saturable kinetics and complete metabolization within 48 h. All tested Mws exhibited a similar uptake by liver cells and metabolization into activated sugars. 13Clabelling combined with LC?MS provides an excellent approach to elucidating in vivo fate and biological activities of hyaluronan.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/EF16_026%2F0008451" target="_blank" >EF16_026/0008451: Engineering of new biomaterials and biopharmaceuticals for the diagnosis and treatment of the cerebrovascular and neurodegenerative diseases</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)