Local Wnt signalling in the asymmetric migrating vertebrate cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00557419" target="_blank" >RIV/68081707:_____/22:00557419 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/22:00125589
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1084952121003025?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1084952121003025?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.semcdb.2021.11.020" target="_blank" >10.1016/j.semcdb.2021.11.020</a>
Alternative languages
Result language
angličtina
Original language name
Local Wnt signalling in the asymmetric migrating vertebrate cells
Original language description
Wnt signalling is known to generate cellular asymmetry via Wnt/planar cell polarity pathway (Wnt/PCP). Wnt/ PCP acts locally (i) to orient membrane polarity and asymmetric establishment of intercellular junctions via conserved set of PCP proteins most specifically represented by Vangl and Prickle, and (ii) to asymmetrically rearrange cytoskeletal structures via downstream effectors of Dishevelled (Dvl). This process is best described on stable phenotypes of epithelial cells. Here, however, we review the activity of Wnt signalling in migratory cells which experience the extensive rearrangements of cytoskeleton and consequently dynamic asymmetry, making the localised effects of Wnt signalling easier to distinguish. Firstly, we focused on migration of neuronal axons, which allows to study how the pre-existent cellular asymmetry can influence Wnt signalling outcome. Then, we reviewed the role of Wnt signalling in models of mesenchymal migration including neural crest, melanoma, and breast cancer cells. Last, we collected evidence for local Wnt signalling in amoeboid cells, especially lymphocytes. As the outcome of this review, we identify blank spots in our current understanding of this topic, propose models that synthesise the current observations and allow formulation of testable hypotheses for the future research.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/GX19-28347X" target="_blank" >GX19-28347X: Molecular and functional analysis of casein kinase 1 biology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Seminars in Cell & Developmental Biology
ISSN
1084-9521
e-ISSN
1096-3634
Volume of the periodical
125
Issue of the periodical within the volume
MAY 2022
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
26-36
UT code for WoS article
000791277000005
EID of the result in the Scopus database
2-s2.0-85121279544