All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Exploring Sequence Space to Design Controllable G-Quadruplex Topology Switches

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00563710" target="_blank" >RIV/68081707:_____/22:00563710 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989592:15640/22:73618759

  • Result on the web

    <a href="https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202101357" target="_blank" >https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202101357</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.31635/ccschem.021.202101357" target="_blank" >10.31635/ccschem.021.202101357</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Exploring Sequence Space to Design Controllable G-Quadruplex Topology Switches

  • Original language description

    As nonclassical nucleic acid structures, G-quadruplexes (G4s) not only play important roles in gene regulation and stability maintenance, but are also widely used in nanotechnology. Structural diversity is one of the main factors explaining the popularity of G4s, but a comprehensive and integrated study of different factors determining G4 structural versatility is currently lacking. Herein, starting from a common G4 sequence, (G3T)3G3, as the parent chain, and then taking advantage of G4 versatility, we present a variety of strategies to control G4 structure, based on the regulation of loop length and flanking sequences, cation (type and concentration), and molecular crowding. These strategies allow us to con-vert the G4 topology from parallel to hybrid, to antiparallel, and then back to parallel. Such structural diversity reveals the coding regulation ability of G4 structures, with potential applications in nanotechnology.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    CCS CHEMISTRY

  • ISSN

    2096-5745

  • e-ISSN

    2096-5745

  • Volume of the periodical

    4

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    CN - CHINA

  • Number of pages

    15

  • Pages from-to

    3036-3050

  • UT code for WoS article

    000871904500004

  • EID of the result in the Scopus database

    2-s2.0-85137921193