Exploring Sequence Space to Design Controllable G-Quadruplex Topology Switches
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00563710" target="_blank" >RIV/68081707:_____/22:00563710 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15640/22:73618759
Result on the web
<a href="https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202101357" target="_blank" >https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202101357</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.31635/ccschem.021.202101357" target="_blank" >10.31635/ccschem.021.202101357</a>
Alternative languages
Result language
angličtina
Original language name
Exploring Sequence Space to Design Controllable G-Quadruplex Topology Switches
Original language description
As nonclassical nucleic acid structures, G-quadruplexes (G4s) not only play important roles in gene regulation and stability maintenance, but are also widely used in nanotechnology. Structural diversity is one of the main factors explaining the popularity of G4s, but a comprehensive and integrated study of different factors determining G4 structural versatility is currently lacking. Herein, starting from a common G4 sequence, (G3T)3G3, as the parent chain, and then taking advantage of G4 versatility, we present a variety of strategies to control G4 structure, based on the regulation of loop length and flanking sequences, cation (type and concentration), and molecular crowding. These strategies allow us to con-vert the G4 topology from parallel to hybrid, to antiparallel, and then back to parallel. Such structural diversity reveals the coding regulation ability of G4 structures, with potential applications in nanotechnology.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CCS CHEMISTRY
ISSN
2096-5745
e-ISSN
2096-5745
Volume of the periodical
4
Issue of the periodical within the volume
9
Country of publishing house
CN - CHINA
Number of pages
15
Pages from-to
3036-3050
UT code for WoS article
000871904500004
EID of the result in the Scopus database
2-s2.0-85137921193