G-quadruplex ligands as potent regulators of lysosomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00574518" target="_blank" >RIV/68081707:_____/23:00574518 - isvavai.cz</a>

Result on the web

<a href="https://www.tandfonline.com/doi/full/10.1080/15548627.2023.2170071" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/15548627.2023.2170071</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/15548627.2023.2170071" target="_blank" >10.1080/15548627.2023.2170071</a>

Result language

angličtina

Original language name

G-quadruplex ligands as potent regulators of lysosomes

Original language description

Guanine-quadruplex structures (G4) are unusual nucleic acid conformations formed by guanine-rich DNA and RNA sequences and known to control gene expression mechanisms, from transcription to protein synthesis. So far, a number of molecules that recognize G4 have been developed for potential therapeutic applications in human pathologies, including cancer and infectious diseases. These molecules are called G4 ligands. When the biological effects of G4 ligands are studied, the analysis is often limited to nucleic acid targets. However, recent evidence indicates that G4 ligands may target other cellular components and compartments such as lysosomes and mitochondria. Here, we summarize our current knowledge of the regulation of lysosome by G4 ligands, underlying their potential functional impact on lysosome biology and autophagic flux, as well as on the transcriptional regulation of lysosomal genes. We outline the consequences of these effects on cell fate decisions and we systematically analyzed G4-prone sequences within the promoter of 435 lysosome-related genes. Finally, we propose some hypotheses about the mechanisms involved in the regulation of lysosomes by G4 ligands.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Autophagy

ISSN

1554-8627

e-ISSN

1554-8635

Volume of the periodical

19

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

1901-1915

UT code for WoS article

000924871700001

EID of the result in the Scopus database

2-s2.0-85147680783