Cell-type specific anti-cancerous effects of nitro-oleic acid and its combination with gamma irradiation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00583536" target="_blank" >RIV/68081707:_____/23:00583536 - isvavai.cz</a>
Result on the web
<a href="https://www.degruyter.com/document/doi/10.1515/hsz-2023-0150/html" target="_blank" >https://www.degruyter.com/document/doi/10.1515/hsz-2023-0150/html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/hsz-2023-0150" target="_blank" >10.1515/hsz-2023-0150</a>
Alternative languages
Result language
angličtina
Original language name
Cell-type specific anti-cancerous effects of nitro-oleic acid and its combination with gamma irradiation
Original language description
Nitro-fatty acids (NFAs) are endogenous lipid mediators capable of post-translational modifications of selected regulatory proteins. Here, we investigated the anti-cancerous effects of nitro-oleic acid (NO(2)OA) and its combination with gamma irradiation on different cancer cell lines. The effects of NO(2)OA on cell death, cell cycle distribution, or expression of p21 and cyclin D1 proteins were analyzed in cancer (A-549, HT-29 and FaDu) or normal cell lines (HGF, HFF-1). Dose enhancement ratio at 50?% survival fraction (DERIC50) was calculated for samples pre-treated with NO(2)OA followed by gamma irradiation. NO(2)OA suppressed viability and induced apoptotic cell death. These effects were cell line specific but not in general selective for cancer cells. HT-29 cell line exerted higher sensitivity toward NO(2)OA treatment among cancer cell lines tested: induction of cell cycle arrest in the G2/M phase was associated with an increase in p21 and a decrease in cyclin D1 expression. Pre-treatment of HT-29 cells with NO(2)OA prior irradiation showed a significantly increased DERIC50, demonstrating radiosensitizing effects. In conclusion, NO(2)OA exhibited potential for combined chemoradiotherapy. Our results encourage the development of new NFAs with improved features for cancer chemoradiation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biological Chemistry
ISSN
1431-6730
e-ISSN
1437-4315
Volume of the periodical
2023
Issue of the periodical within the volume
SEP 15 2023
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
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UT code for WoS article
001067412100001
EID of the result in the Scopus database
2-s2.0-85171733621