Z-DNA interaction proteins insights from ChIP-seq data
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F25%3A00641690" target="_blank" >RIV/68081707:_____/25:00641690 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26310/26:0200528
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0006291X25016262?pes=vor&utm_source=clarivate&getft_integrator=clarivate" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0006291X25016262?pes=vor&utm_source=clarivate&getft_integrator=clarivate</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbrc.2025.152910" target="_blank" >10.1016/j.bbrc.2025.152910</a>
Alternative languages
Result language
angličtina
Original language name
Z-DNA interaction proteins insights from ChIP-seq data
Original language description
Z-DNA is a noncanonical left-handed DNA conformation implicated in gene regulation and genome dynamics. Despite its biological relevance, the landscape of Z-DNA-binding proteins (ZBPs) in the human genome remains poorly characterized. In this study, we used the Z-Hunter algorithm to predict Z-DNA-forming sequences throughout the human genome. These predicted regions were then systematically overlaid with transcription factor (TF) binding profiles from the ChIP-Atlas database to identify proteins that co-localize with Z-DNA motifs. Our integrative analysis identified a diverse set of candidate ZBPs, including both known ZBP homologs and several TF, suggesting a broader regulatory role for Z-DNA in transcriptional control. This work provides a valuable resource for exploring the Z-DNA-protein interaction network and its potential implications for human health and disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochemical and Biophysical Research Communications
ISSN
0006-291X
e-ISSN
1090-2104
Volume of the periodical
790
Issue of the periodical within the volume
NOV 19 2025
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
152910
UT code for WoS article
001611185700002
EID of the result in the Scopus database
2-s2.0-105020272957