Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F25%3A00643357" target="_blank" >RIV/68081707:_____/25:00643357 - isvavai.cz</a>
Result on the web
<a href="https://academic.oup.com/nar/article/53/22/gkaf1288/8363854" target="_blank" >https://academic.oup.com/nar/article/53/22/gkaf1288/8363854</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nar/gkaf1288" target="_blank" >10.1093/nar/gkaf1288</a>
Alternative languages
Result language
angličtina
Original language name
Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences
Original language description
Interactions between biomolecules govern cellular biology. While protein/protein and protein/nucleic acid (DNA, RNA) interactions-and, to a lesser extent, RNA/RNA and RNA/DNA interactions-have been extensively described, a question remains as to whether and how non-canonical DNA structures might interact with each other. This is of particular interest for guanine (G)-rich sequences that can fold into G-quadruplex (G4) structures: Individual G4s are currently studied for their involvement in a myriad of cellular events (mostly pertaining to the control of gene expression), and, more recently, the interactions between two G4s have been scrutinized as being part of a novel gene expression regulatory mechanism involving chromatin remodeling through G4-mediated loop formation. The question that needs to be answered is whether G4s or their corresponding G-rich sequences are involved. We present here a series of results collected using a combination of sequences, experimental conditions, and techniques, which led us to the conclusion that G4/G4 intermolecular interactions are mostly governed by primary sequence interactions in vitro.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nucleic Acids Research
ISSN
0305-1048
e-ISSN
1362-4962
Volume of the periodical
53
Issue of the periodical within the volume
22
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
gkaf1288
UT code for WoS article
001629554600001
EID of the result in the Scopus database
2-s2.0-105023764936