Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081715%3A_____%2F20%3A00524331" target="_blank" >RIV/68081715:_____/20:00524331 - isvavai.cz</a>
Result on the web
<a href="http://hdl.handle.net/11104/0308692" target="_blank" >http://hdl.handle.net/11104/0308692</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yjmcc.2020.04.012" target="_blank" >10.1016/j.yjmcc.2020.04.012</a>

Result language
angličtina
Original language name
Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response
Original language description
The effect of ER stress on protein secretion by cardiac myocytes using ER stressors thapsigargin (TG), which depletes ER calcium, and tunicamycin (TM) was studied. Proteomic analyses of TG- and TM-conditioned media showed that the secretion of most proteins was inhibited by TG and TM, however, secretion of several ER-resident proteins, including GRP78 was increased by TG but not TM. Simulated ischemia, which decreases SR/ER calcium also increased secretion of these proteins. The proteins secreted during ER stress mediated by ER calcium depletion can enhance cardiac myocyte viability.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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