Subspecific origin and haplotype diversity in the laboratory mouse

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F11%3A00360034" target="_blank" >RIV/68081766:_____/11:00360034 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/ng.847" target="_blank" >http://dx.doi.org/10.1038/ng.847</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ng.847" target="_blank" >10.1038/ng.847</a>

Result language

angličtina

Original language name

Subspecific origin and haplotype diversity in the laboratory mouse

Original language description

Here we provide a genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes of wild-caught mice from three subspecies of Mus musculus. We show that classical laboratory strains are derived from a few fancy mice with limited haplotype diversity. Their genomes are overwhelmingly Mus musculus domesticus in origin, and the remainder is mostly of Japanese origin. We generated genome-wide haplotype maps based on identity by descent from fancy mice and show that classical inbred strains have limited and non-randomly distributed genetic diversity. In contrast, wild-derived laboratory strains represent a broad sampling of diversity within M. musculus. Intersubspecific introgression is pervasive in these strains, and contamination by laboratory stocks has played a role in this process.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA206%2F08%2F0640" target="_blank" >GA206/08/0640: Immunogenetic study of a house mouse hybrid zone</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Genetics

ISSN

1061-4036

e-ISSN

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Volume of the periodical

45

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

648-655

UT code for WoS article

000292184600008

EID of the result in the Scopus database

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