All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F22%3A00562222" target="_blank" >RIV/68081766:_____/22:00562222 - isvavai.cz</a>

  • Result on the web

    <a href="https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02772-1" target="_blank" >https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02772-1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1186/s13059-022-02772-1" target="_blank" >10.1186/s13059-022-02772-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice

  • Original language description

    Background The laboratory mouse was domesticated from the wild house mouse. Understanding the genetics underlying domestication in laboratory mice, especially in the widely used classical inbred mice, is vital for studies using mouse models. However, the genetic mechanism of laboratory mouse domestication remains unknown due to lack of adequate genomic sequences of wild mice. Results We analyze the genetic relationships by whole-genome resequencing of 36 wild mice and 36 inbred strains. All classical inbred mice cluster together distinctly from wild and wild-derived inbred mice. Using nucleotide diversity analysis, Fst, and XP-CLR, we identify 339 positively selected genes that are closely associated with nervous system function. Approximately one third of these positively selected genes are highly expressed in brain tissues, and genetic mouse models of 125 genes in the positively selected genes exhibit abnormal behavioral or nervous system phenotypes. These positively selected genes show a higher ratio of differential expression between wild and classical inbred mice compared with all genes, especially in the hippocampus and frontal lobe. Using a mutant mouse model, we find that the SNP rs27900929 (T>C) in gene Astn2 significantly reduces the tameness of mice and modifies the ratio of the two Astn2 (a/b) isoforms. Conclusion Our study indicates that classical inbred mice experienced high selection pressure during domestication under laboratory conditions. The analysis shows the positively selected genes are closely associated with behavior and the nervous system in mice. Tameness may be related to the Astn2 mutation and regulated by the ratio of the two Astn2 (a/b) isoforms.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10613 - Zoology

Result continuities

  • Project

    <a href="/en/project/GA16-23773S" target="_blank" >GA16-23773S: Phylogeography, selection and mutation rate at the whole-genome level: Inference from mtDNA sequences of the house mouse</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Genome Biology

  • ISSN

    1474-760X

  • e-ISSN

    1474-760X

  • Volume of the periodical

    23

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    23

  • Pages from-to

    203

  • UT code for WoS article

    000859917800001

  • EID of the result in the Scopus database

    2-s2.0-85138951970