Adenine N3 is a main alkylation site of styrene oxide in double-stranded DNA.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F01%3A19010042" target="_blank" >RIV/68378041:_____/01:19010042 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Adenine N3 is a main alkylation site of styrene oxide in double-stranded DNA.
Original language description
The results indicated that in double-stranded DNA N-7 of guanine and N-3 of adenine account for 97% of alkylation by SO. However, these abundant adducts are not stable, the half-life of depurination in DNA for 3-substituted adenines being ~ 10 and ~ 20 h, for ?- and -isomers, respectively, and 51 h for both isomers of 7-substituted guanines.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA313%2F99%2F1460" target="_blank" >GA313/99/1460: Mechanisms of genotoxic effects and prospects to the evaluation of individual susceptibility to styrene exposure</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemico-Biological Interactions
ISSN
0009-2797
e-ISSN
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Volume of the periodical
124
Issue of the periodical within the volume
N/A
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
15
Pages from-to
13-27
UT code for WoS article
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EID of the result in the Scopus database
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