The Developing Mouse Dentition - a new tool for apoptosis study.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F03%3A19043003" target="_blank" >RIV/68378041:_____/03:19043003 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The Developing Mouse Dentition - a new tool for apoptosis study.
Original language description
We proposed a hypothesis to explain the stimulation of apoptosis in the dental epithelium by integrating two concepts:(1) The regulation of epithelial bidding by positional information generated from interactions between growth-activating and growth-inhibiting signals, and (2) apoptosis stimulation by the failure of death-suppressing signals. During the budding of the dental epithelium, local excess in growth inhibitors (e.g.,Bmps)might lead to the epithelial cells' failure to receive adequate growth-activating (apoptosis-suppressing) signals. The resulting signal imbalance leads to cell suicide by apoptosis. Understanding of apoptosis regulation in the vestigial tooth primordia can help to elucidate the mechanism of their suppression during evolutionand to identify factors essential for tooth survival. The latter knowledge will be important for developing a technology of tooth engineering.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Project
<a href="/en/project/GA304%2F02%2F0448" target="_blank" >GA304/02/0448: Budding morphogenesis as a mechanism of dentition development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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