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Air pollution by c-PAHs and plasma levels of p53 and p21WAF1 proteins

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F07%3A00087285" target="_blank" >RIV/68378041:_____/07:00087285 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378041:_____/07:00342033

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Air pollution by c-PAHs and plasma levels of p53 and p21WAF1 proteins

  • Original language description

    In total 200 exposed subjects (city policemen, bus drivers and controls from Prague, Kosice and Sofia) was analyzed the effect of exposure to carcinogenic PAHs in ambient air on the plasma levels of p53 and p21WAF1 (accepted as universal markers of genotoxic stress and DNA damage). In all subjects p53 plasma levels were positively correlated with p21WAF1 levels, exposure to B[a]P, c-PAHs and levels of total DNA adducts.

  • Czech name

    Znečištění ovzduší k-PAU a hladiny p53 a p21WAF1 proteinů v plazmě

  • Czech description

    U 200 exponovaných osob (městští strážníci, řidiči autobusů a kontrolní skupiny z Prahy, Košic a Sofie) byl studován účinek expozice karcinogenním PAU v ovzduší na hladiny proteinů p53 a p21WAF1 v plazmě (tyto proteiny jsou akceptovány jako univerzální markery genotoxického stresu a poškození DNA). U všech osob byla zjištěna pozitivní korelace mezi hladinou p53 v plazmě a hladinou p21WAF1, expozicí B[a]P, karc-PAU a hladinou DNA aduktů.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    DN - Environmental impact on health

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>R - Projekt Ramcoveho programu EK

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Mutation Research

  • ISSN

    0027-5107

  • e-ISSN

  • Volume of the periodical

    620

  • Issue of the periodical within the volume

    -

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    7

  • Pages from-to

    34-40

  • UT code for WoS article

  • EID of the result in the Scopus database