NMDA receptor-dependent GABA(B) receptor internalization via CaMKII phosphorylation of serine 867 in GABA(B1)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F10%3A00347602" target="_blank" >RIV/68378041:_____/10:00347602 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
NMDA receptor-dependent GABA(B) receptor internalization via CaMKII phosphorylation of serine 867 in GABA(B1)
Original language description
We have found that NMDA receptor activation promotes dynamin-dependent endocytosis of GABA(B) receptors by Ca2+/Calmodulin-dependent protein kinase II (CaMKII) mechanism. CaMKII associates with GABA(B) in vivo and phosphorylates serine 867 (S867) in theintracellular C terminus of the GABA(B1) subunit. Time-lapse two-photon imaging of organotypic hippocampal slices reveals that activation of NMDA receptors removes GABA(B) receptors within minutes from the surface of dendritic spines and shafts. NMDA-dependent GABA(B) internalization is represents a novel form of synaptic plasticity
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
107
Issue of the periodical within the volume
31
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
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UT code for WoS article
000280605900067
EID of the result in the Scopus database
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