1,3-Butadiene: Biomarkers and application to risk assessment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F11%3A00350229" target="_blank" >RIV/68378041:_____/11:00350229 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.cbi.2010.10.010" target="_blank" >http://dx.doi.org/10.1016/j.cbi.2010.10.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cbi.2010.10.010" target="_blank" >10.1016/j.cbi.2010.10.010</a>

Result language
angličtina
Original language name
1,3-Butadiene: Biomarkers and application to risk assessment
Original language description
1,3-Butadiene (BD) is a known human carcinogen that is metabolized mainly by P450 2E1 to three epoxides (EB, DEB and EB-diol). These epoxides vary in their mutagenic potency, with DEB being the most mutagenic metabolite. It is important to understand theinternal formation of the individual epoxides to assign the relative risk for each metabolite and to understand the molecular mechanisms responsible for differences in carcinogenicity. In the extensive exposure-biomarker studies on mice, rats and humanswas found that using low exposures that range from current occupational levels to human exposures from tobacco smoke mice are very different from humans, with mice forming 200 times more DEB than humans at exposures of 0.1-1.5ppm BD. These data providea scientific basis for improved risk assessment of BD.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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