Sex-Specific Formation of 1,2:3,4-Diepoxybutane-Derived Hemoglobin Adducts in 1,3-Butadiene-Exposed Workers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00635580" target="_blank" >RIV/68378041:_____/25:00635580 - isvavai.cz</a>

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acs.chemrestox.4c00530" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.chemrestox.4c00530</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.chemrestox.4c00530" target="_blank" >10.1021/acs.chemrestox.4c00530</a>

Result language

angličtina

Original language name

Sex-Specific Formation of 1,2:3,4-Diepoxybutane-Derived Hemoglobin Adducts in 1,3-Butadiene-Exposed Workers

Original language description

1,3-Butadiene (BD) is an important industrial chemical that is classified as a human carcinogen. BD carcinogenicity has been attributed to several reactive epoxide metabolites, and the formation of highly mutagenic 1,2:3,4-diepoxybutane (DEB) has been suggested to drive mutagenesis and carcinogenesis at exposures experienced in humans. We report herein the formation of DEB-specific N,N-(2,3-dihydroxy-1,4-butadiyl)-valine (pyr-Val) in occupationally BD-exposed workers as an indirect biomarker of DEB-induced mutagenicity. pyr-Val was determined in BD-monomer and -polymer plant workers that had been previously analyzed for several other biomarkers of exposure and effect. In this second study, pyr-Val was detected in 92 out of 94 (98%) individuals, ranging from 0.001 to 0.697 pmol/g of globin. Surprisingly, pyr-Val was observed in 43 of 44 administrative control subjects not known to be exposed to BD, suggesting environmental sources of BD. The mean ± SD amounts of pyr-Val were 0.049 ± 0.044, 0.029 ± 0.032, 0.030 ± 0.035, and 0.074 ± 0.093 pmol/g globin in female control, female exposed, male control, and male exposed, respectively, clearly demonstrating the formation of DEB in environmentally and occupationally exposed BD workers. The amounts of pyr-Val found in this study suggest that humans are much less efficient in the formation of DEB than mice or rats at similar BD exposures. The formation of pyr-Val was lower than that associated with increased mutagenesis in rodents.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical Research in Toxicology

ISSN

0893-228X

e-ISSN

1520-5010

Volume of the periodical

38

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

858-864

UT code for WoS article

001472493300001

EID of the result in the Scopus database

2-s2.0-105003776857