Formation of 1,2; 3,4-diepoxybutane specific hemoglobin adducts in 1,3-butadiene exposed workers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00372929" target="_blank" >RIV/68378041:_____/12:00372929 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1093/toxsci/kfr272" target="_blank" >http://dx.doi.org/10.1093/toxsci/kfr272</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/toxsci/kfr272" target="_blank" >10.1093/toxsci/kfr272</a>

Result language

angličtina

Original language name

Formation of 1,2; 3,4-diepoxybutane specific hemoglobin adducts in 1,3-butadiene exposed workers

Original language description

1,3-butadiene (BD) carcinogenicity has been attributed to its metabolism to several reactive epoxide metabolites and formation of the highly mutagenic 1,2:3,4-diepoxybutane (DEB) has been hypothesized to drive mutagenesis and carcinogenesis at exposuresexperienced in humans. This work reports the formation of DEB-specific pyr-Val in BD-exposed workers as a biomarker of DEB formation. The results suggest that formation of DEB relative to other epoxides is significantly different in the highest exposed polymer workers compared to controls and BD monomer workers.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicological Sciences

ISSN

1096-6080

e-ISSN

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Volume of the periodical

125

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

30-40

UT code for WoS article

000298734400005

EID of the result in the Scopus database

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