Ancestral susceptibility to colorectal cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00373767" target="_blank" >RIV/68378041:_____/12:00373767 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/12:11925

Result on the web

<a href="http://dx.doi.org/10.1093/mutage/ger061" target="_blank" >http://dx.doi.org/10.1093/mutage/ger061</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/mutage/ger061" target="_blank" >10.1093/mutage/ger061</a>

Result language

angličtina

Original language name

Ancestral susceptibility to colorectal cancer

Original language description

Several studies have shown that susceptibility to complex diseases can be mediated by ancestral alleles. Using RNAi screening, CTNNBL1 was identified as a putative regulator of the Wnt signaling pathway, which plays a key role in colorectal carcinogenesis. Recently, single nucleotide polymorphisms (SNPs) in CTNNBL1 have been associated with obesity, a known risk factor for CRC. We investigated whether genetic variation in CTNNBL1 affects susceptibility to CRC and tested for signals of recent selection.In the Czech cohort, containing sporadic cases, the ancestral alleles of three SNPs showed evidence of association with CRC: rs2344481 (OR 1.44, 95%CI 1.06-1.95, dominant model), rs2281148 (OR 0.59, 95%CI 0.36-0.96, dominant model) and rs2235460 (OR 1.38, 95%CI 1.01-1.89, AA vs. GG). Data derived from several databases and statistical tests consistently pointed to a likely shaping of CTNNBL1 by positive selection.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mutagenesis

ISSN

0267-8357

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

197-204

UT code for WoS article

000300040200008

EID of the result in the Scopus database

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