Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2 '-deoxyguanosine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F13%3A00395220" target="_blank" >RIV/68378041:_____/13:00395220 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1089/ars.2012.4714" target="_blank" >http://dx.doi.org/10.1089/ars.2012.4714</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/ars.2012.4714" target="_blank" >10.1089/ars.2012.4714</a>

Result language
angličtina
Original language name
Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2 '-deoxyguanosine
Original language description
This is the first comprehensive study of both human and methodological factors influencing 8-oxodG measurement, providing key information for future studies with this important biomarker. Conclusion: ELISA variability is greater than chromatographic assay variability, and cannot determine absolute levels of 8-oxodG. Use of standardized calibrants greatly improves intra-technique agreement and, for the chromatographic assays, importantly allows integration of results for pooled analyses. If 24?h samplesare not feasible, creatinine- or SG-adjusted first morning samples are recommended.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/GAP503%2F11%2F0084" target="_blank" >GAP503/11/0084: The effect of polycyclic aromatic hydrocarbons and particulate matter on DNA damage and DNA repair mechanisms in vitro</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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