Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F13%3A00395370" target="_blank" >RIV/68378041:_____/13:00395370 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.mrfmmm.2013.02.003" target="_blank" >http://dx.doi.org/10.1016/j.mrfmmm.2013.02.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mrfmmm.2013.02.003" target="_blank" >10.1016/j.mrfmmm.2013.02.003</a>

Result language

angličtina

Original language name

Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments

Original language description

Gene expression levels are significantly regulated by DNA methylation. In this study the methylation profiles in children (7-15 years) with and without asthma from two regions with different levels of air pollution (a highly polluted Ostrava region and acontrol Prachatice region) were studied. Results demonstrate a significant impact of different environmental conditions on the DNA methylation patterns of children from the two regions. No difference in DNA methylation patterns was found between children with and without bronchial asthma in individual locations, but patterns in both asthmatic and healthy children differed between Ostrava and Prachatice. Further, differences in DNA methylation pattern depending on gender and urinary cotinine levels wereobserved. Other factors including lenght of gestation, birth weight and lenght of full breastfeeding are suggested as possible factors that can impact the DNA methylation pattern in future life.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

ISSN

0027-5107

e-ISSN

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Volume of the periodical

741-742

Issue of the periodical within the volume

January

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

18-26

UT code for WoS article

000318456400003

EID of the result in the Scopus database

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