The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F13%3A00396572" target="_blank" >RIV/68378041:_____/13:00396572 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.neulet.2013.08.042" target="_blank" >http://dx.doi.org/10.1016/j.neulet.2013.08.042</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neulet.2013.08.042" target="_blank" >10.1016/j.neulet.2013.08.042</a>
Alternative languages
Result language
angličtina
Original language name
The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice
Original language description
The strength of the acoustic startle response (ASR) to short bursts of broadband noise or tone pips (4, 8 and 16 kHz) and the prepulse inhibition (PPI) of the ASR elicited by prepulse tones (4, 8 and 16 kHz) were measured in parvalbumin-deficient (PV-/-)mice and in age-matched PV+/+ mice as controls. In PV-/- mice, we observed smaller ASR amplitudes in response to relatively weak startling stimuli (80-90 dB SPL) of either broadband noise or 8-kHz tones compared to those recorded in PV+/+ mice. For these startling stimuli, PV-/- mice had higher ASR thresholds and longer ASR latencies. PPI of the ASR in PV-/- mice was less effective than in PV+/+ mice, for all tested prepulse frequencies (4, 8 or 16 kHz) at 70 dB SPL. Our findings demonstrate no effectof PV deficiency on hearing threshold as determined from recordings of auditory brainstem responses in PV -/- mice. However, the frequency-specific differences in the ASR and the significant reduction of PPI of ASR reflect specific change
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroscience Letters
ISSN
0304-3940
e-ISSN
—
Volume of the periodical
553
Issue of the periodical within the volume
October
Country of publishing house
IE - IRELAND
Number of pages
5
Pages from-to
216-220
UT code for WoS article
000326008700041
EID of the result in the Scopus database
—