A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F14%3A00435536" target="_blank" >RIV/68378041:_____/14:00435536 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production

Original language description

A low-molecular weight dialyzable leukocyte extract (called transfer factor) has been used for many years in clinic to improve or modulate immune response. However, the mechanism of its action remained obscure. Here we showed that transfer factor modulates the production of various cytokines by activated T cells and that the most profound immunoregulatory effect of transfer factort can be seen on the development of Th17 cells and interleukin-17 productiion. Transfer factor significantly enhanced the production of proinflammatory cytokine IL-17.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

—

Project

<a href="/en/project/LO1309" target="_blank" >LO1309: Cell Therapy and Tissue Repair</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

—

Volume of the periodical

60

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

253-260

UT code for WoS article

000347748000001

EID of the result in the Scopus database

—