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Chromosomal damage as markers of genotoxic effect and carcinogenesis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F15%3A00475586" target="_blank" >RIV/68378041:_____/15:00475586 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Chromosomal damage as markers of genotoxic effect and carcinogenesis

  • Original language description

    Many cancers often arise from cells unable to maintain genomic and chromosomal instability. Recurrent chromosomal aberrations (CAs) arise through a clonal growth of cells with specific translocations, deletions or amplifications of chromosomal regions or whole chromosomes and many specific CAs are causative events in malignant transformation. In our studies we compared frequencies of CAs in patients with incident lung, breast and colorectal cancer. Additionally, we have also searched for genetic background that modulates chromosomal instability in humans. The DNA repair characteristics have been discussed as well.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů