Brain Diffusivity and Structural Changes in the R6/2 Mouse Model of Huntington Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00476755" target="_blank" >RIV/68378041:_____/17:00476755 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/17:10373797 RIV/00159816:_____/17:00068491
Result on the web
<a href="http://dx.doi.org/10.1002/jnr.23965" target="_blank" >http://dx.doi.org/10.1002/jnr.23965</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jnr.23965" target="_blank" >10.1002/jnr.23965</a>
Alternative languages
Result language
angličtina
Original language name
Brain Diffusivity and Structural Changes in the R6/2 Mouse Model of Huntington Disease
Original language description
Diffusion-weighted magnetic resonance (DW-MR) is an important diagnostic tool in Huntington disease (HD), a fatal hereditary neurodegenerative disorder. To clarify the nature of diffusivity changes in HD, we compared the apparent diffusion coefficient of water (ADC(W)) acquired by DW-MR with extracellular space volume fraction a and tortuosity lambda, measured by the iontophoretic method in the R6/2 mouse model of HD and in wild-type controls (WT). In anisotropic globus pallidus (GP), diffusion measurements were performed in the mediolateral (x), rostrocaudal (y), and ventrodorsal (z) axes. In HD animals, we detected an increase in ADCW in all axes and larger a than in WT mice. No significant difference between WT and HD mice was found in the values of tortuosity (lambda(x), lambda(y), lambda(z)). Despite structural changes in GP, diffusion anisotropy was unaffected in HD mice. Immunohistochemical analysis revealed in HD mice weaker expression of extracellular matrix and a decrease in neuron numbers compared with WT mice. Glial fibrillary acidic protein staining detected astrogliosis-like changes in the morphology of astrocytic processes in HD GP. In the somatosensory cortex, no significant differences in the studied parameters were found. We conclude that in the R6/2 model of HD, a decrease in the number of neurons in the GP results in increased ADC(W) and alpha values. Values of lambda were not significantly changed as the increase of diffusion obstacles formed by reactive astrocytes was compensated for by the extracellular matrix reduction.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroscience Research
ISSN
0360-4012
e-ISSN
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Volume of the periodical
95
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
1474-1484
UT code for WoS article
000402441800011
EID of the result in the Scopus database
2-s2.0-85006350370