Chemically different non-thermal plasmas target distinct cell death pathways

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00477373" target="_blank" >RIV/68378041:_____/17:00477373 - isvavai.cz</a>

Alternative codes found

RIV/68378271:_____/17:00474063 RIV/00023001:_____/17:00075921

Result on the web

<a href="http://dx.doi.org/10.1038/s41598-017-00689-5" target="_blank" >http://dx.doi.org/10.1038/s41598-017-00689-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-017-00689-5" target="_blank" >10.1038/s41598-017-00689-5</a>

Result language

angličtina

Original language name

Chemically different non-thermal plasmas target distinct cell death pathways

Original language description

A rigorous biochemical analysis of interactions between non-thermal plasmas (NTPs) and living cells has become an important research topic, due to recent developments in biomedical applications of non-thermal plasmas. Here, we decouple distinct cell death pathways targeted by chemically different NTPs. We show that helium NTP cells treatment, results in necrosome formation and necroptosis execution, whereas air NTP leads to mTOR activation and autophagy inhibition, that induces mTOR-related necrosis. On the contrary, ozone (abundant component of air NTP) treatment alone, exhibited the highest levels of reactive oxygen species production leading to CypD-related necrosis via the mitochondrial permeability transition. Our findings offer a novel insight into plasma-induced cellular responses, and reveal distinct cell death pathways triggered by NTPs.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10610 - Biophysics

Project

<a href="/en/project/LO1309" target="_blank" >LO1309: Cell Therapy and Tissue Repair</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

apr

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

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UT code for WoS article

000398162400011

EID of the result in the Scopus database

2-s2.0-85017175988