Manipulating the mitochondria activity in human hepatic cell line Huh7 by low-power laser irradiation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00493199" target="_blank" >RIV/68378041:_____/18:00493199 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/18:00489933 RIV/00023001:_____/18:00076546
Result on the web
<a href="http://dx.doi.org/10.1364/BOE.9.001283" target="_blank" >http://dx.doi.org/10.1364/BOE.9.001283</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1364/BOE.9.001283" target="_blank" >10.1364/BOE.9.001283</a>
Alternative languages
Result language
angličtina
Original language name
Manipulating the mitochondria activity in human hepatic cell line Huh7 by low-power laser irradiation
Original language description
Low-power laser irradiation of red light has been recognized as a promising tool across a vast variety of biomedical applications. However, deep understanding of the molecular mechanisms behind laser-induced cellular effects remains a significant challenge. Here, we investigated mechanisms involved in the death process in human hepatic cell line Huh7 at a laser irradiation. We decoupled distinct cell death pathways targeted by laser irradiations of different powers. Our data demonstrate that high dose laser irradiation exhibited the highest levels of total reactive oxygen species production, leading to cyclophilin D-related necrosis via the mitochondrial permeability transition. On the contrary, low dose laser irradiation resulted in the nuclear accumulation of superoxide and apoptosis execution. Our findings offer a novel insight into laser-induced cellular responses, and reveal distinct cell death pathways triggered by laser irradiation. The observed link between mitochondria depolarization and triggering ROS could be a fundamental phenomenon in laser-induced cellular responses.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/LO1309" target="_blank" >LO1309: Cell Therapy and Tissue Repair</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Optics Express
ISSN
2156-7085
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
1283-1300
UT code for WoS article
000426743300028
EID of the result in the Scopus database
2-s2.0-85042686703