Light-induced modulation of the mitochondrial respiratory chain activity: possibilities and limitations

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00540551" target="_blank" >RIV/68378041:_____/20:00540551 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/20:00534420 RIV/00216208:11110/20:10412793 RIV/00023001:_____/20:00079468
Result on the web
<a href="https://link.springer.com/article/10.1007/s00018-019-03321-z" target="_blank" >https://link.springer.com/article/10.1007/s00018-019-03321-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00018-019-03321-z" target="_blank" >10.1007/s00018-019-03321-z</a>

Result language
angličtina
Original language name
Light-induced modulation of the mitochondrial respiratory chain activity: possibilities and limitations
Original language description
Biological effects of high fluence low-power (HFLP) lasers have been reported for some time, yet the molecular mechanisms procuring cellular responses remain obscure. A better understanding of the effects of HFLP lasers on living cells will be instrumental for the development of new experimental and therapeutic strategies. Therefore, we investigated sub-cellular mechanisms involved in the laser interaction with human hepatic cell lines. We show that mitochondria serve as sub-cellular “sensor” and “effector” of laser light non-specific interactions with cells. We demonstrated that despite blue and red laser irradiation results in similar apoptotic death, cellular signaling and kinetic of biochemical responses are distinct. Our findings reveal the mechanism how HFLP laser irradiation interfere with cell homeostasis and underscore that such laser irradiation permits remote control of mitochondrial function in the absence of chemical or biological agents.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)

Project
<a href="/en/project/EF16_019%2F0000760" target="_blank" >EF16_019/0000760: Solid State Physics for 21st century</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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