Comparison of Phenotype and Secretory Functions of Mesenchymal Stem Cells Isolated from Patients Suffering from Amyotrophic Lateral Sclerosis and Healthy Donors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00491792" target="_blank" >RIV/68378041:_____/17:00491792 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Comparison of Phenotype and Secretory Functions of Mesenchymal Stem Cells Isolated from Patients Suffering from Amyotrophic Lateral Sclerosis and Healthy Donors
Original language description
Mesenchymal stem cells (MSCs) exert extensive differentiation potential and immunomodulatory properties. These properties make them a promising therapeutic tool providing several ways to improve prognosis and course of immedicable disorders such as amyotrophic lateral sclerosis (ALS). The choice between autologous and allogeneic MSC therapy is crucial, because there are studies demonstrating influence of ALS on properties of MSCs isolated from patients suffering from ALS. We tested both types of MSCs and conclude that we did not find any statistically significant differences in phenotype and production of selected soluble molecules between MSCs from healthy donors and patients suffering from ALS.
Czech name
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Czech description
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Project
<a href="/en/project/LO1309" target="_blank" >LO1309: Cell Therapy and Tissue Repair</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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