Gene Therapy and Drug Delivery: the Future of Cancer Treatment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00500145" target="_blank" >RIV/68378041:_____/18:00500145 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Gene Therapy and Drug Delivery: the Future of Cancer Treatment
Original language description
The microRNA(miRNA)-34a is an important regulator of tumor suppression: it controls the expression of several target proteins involved in the cell cycle, differentiation and apoptosis, and antagonizes the processes that are necessary for basic cancer cell viability as well as cancer stemness, metastasis, and chemoresistance. nGiven the anti-oncogenic activity of miR-34a, the substantial benefits of a new therapeutic concept based on nanotechnology delivery of miRNA were proved in this study using biocompatible fluorescent nanodiamond particles in order to treat prostate cancer.nOur findings suggest that the replacement of oncosuppressor miRNA-34a provides an effective strategy for cancer therapy and the nanodiamonds-based delivery system seems to be an excellent system for safe and effective targeting of the tumor.n
Czech name
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Czech description
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Project
<a href="/en/project/LO1508" target="_blank" >LO1508: Genomics and proteomics in the study of mechanisms of biological effects of produced nanoparticles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Nanostructures in Biomedicine: Their Regenerative and toxic properties
ISBN
978-80-906655-7-6
Number of pages of the result
5
Pages from-to
178-182
Number of pages of the book
198
Publisher name
Proxima Tisk, s.r.o.
Place of publication
Praha 3
UT code for WoS chapter
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