Autophagy and Its Role in Spinal Cord Injury

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00500147" target="_blank" >RIV/68378041:_____/18:00500147 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Autophagy and Its Role in Spinal Cord Injury
Original language description
Autophagy is a widely studied process involved in maintaining cellular homeostasis, clearance and degradation of faulty or excess proteins and organelles and ultimately in refreshing the intracellular space. It is highly regulated and constitutively present in cells across species. Defects in autophagy have been associated with a number of pathologies, such as cancer or neurodegenerative diseases often linked with accumulation of misfolded or aggregated proteins. It has been shown to be active after trauma to the spinal cord and may be the key target for spinal cord injury (SCI) therapy. In this review, the process of autophagy is described and crucial phases in the development of functional autolysosome are highlighted, both under conditions of nutritional deficits or after SCI along with therapies aiming to enhance it.n
Czech name
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Czech description
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Project
<a href="/en/project/LO1309" target="_blank" >LO1309: Cell Therapy and Tissue Repair</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Nanostructures in Biomedicine: Their Regenerative and toxic properties
ISBN
978-80-906655-7-6
Number of pages of the result
6
Pages from-to
188-193
Number of pages of the book
198
Publisher name
Proxima Tisk, s.r.o.
Place of publication
Praha 3
UT code for WoS chapter
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