Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00508391" target="_blank" >RIV/68378041:_____/19:00508391 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10394083 RIV/00216208:11120/19:43918242 RIV/00216208:11140/19:10394083 RIV/00064190:_____/19:N0000057
Result on the web
<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216666" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216666</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0216666" target="_blank" >10.1371/journal.pone.0216666</a>
Alternative languages
Result language
angličtina
Original language name
Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival
Original language description
Mucins and their glycosylation have been suggested to play an important role in colorectal carcinogenesis. We examined potentially functional genetic variants in the mucin genes or genes involved in their glycosylation with respect to colorectal cancer (CRC) risk and clinical outcome. We genotyped 23 single nucleotide polymorphisms (SNPs) covering 123 SNPs through pairwise linkage disequilibrium (r(2)>0.80) in the MUC1, MUC2, MUC4, MUC5AC, MUC6, and B3GNT6 genes in a hospital-based case-control study of 1532 CRC cases and 1108 healthy controls from the Czech Republic. We also analyzed these SNPs in relation to overall survival and event-free survival in a subgroup of 672 patients. Among patients without distant metastasis at the time of diagnosis, two MUC4 SNPs, rs3107764 and rs842225, showed association with overall survival (HR 1.40, 95% CI 1.08-1.82, additive model, logrank p = 0.004 and HR 0.64, 95% CI 0.42-0.99, recessive model, log-rank p = 0.01, respectively) and event-free survival (HR 1.31, 95% CI 1.03-1.68, log-rank p = 0.004 and HR 0.64, 95% CI 0.42-0.96, log-rank p = 0.006, respectively) after adjustment for age, sex and TNM stage. Our data suggest that genetic variation especially in the transmembrane mucin gene MUC4 may play a role in the survival of CRC and further studies are warranted.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
e0216666
UT code for WoS article
000467949100033
EID of the result in the Scopus database
2-s2.0-85065918218