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The Healing of Oxidative Injuries with Trehalose in UVB-Irradiated Rabbit Corneas

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00517903" target="_blank" >RIV/68378041:_____/19:00517903 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/19:10409296

  • Result on the web

    <a href="https://www.hindawi.com/journals/omcl/2019/1857086/" target="_blank" >https://www.hindawi.com/journals/omcl/2019/1857086/</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2019/1857086" target="_blank" >10.1155/2019/1857086</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The Healing of Oxidative Injuries with Trehalose in UVB-Irradiated Rabbit Corneas

  • Original language description

    Our previous research revealed that trehalose, a nonreducing disaccharide of glucose and an important stress responsive factor, proved to have anti-inflammatory, antiapoptotic, and particularly antioxidant properties in UVB-irradiated corneas. Trehalose reduced oxidative stress in corneas induced by UVB irradiation, by means of a decrease in the antioxidant/prooxidant imbalance in the corneal epithelium. In this study, we demonstrate that trehalose of 3% or 6% concentration in eye drops directly decreases oxidative stress in UVB-irradiated corneas, by removing the excessive amount of reactive oxygen species (ROS). Trehalose drops applied on corneas during UVB irradiation once daily for four days resulted in a reduction or even absence of the oxidative stress, DNA damage, and peroxynitrite formation (detected by nitrotyrosine residues), seen in buffer-treated corneas. Furthermore, trehalose treatment applied curatively after repeated irradiation for the subsequent fourteen days led to the renewal of corneal transparency and significant suppression or even absence of neovascularization. This was in contrast to buffer-treated irradiated corneas, where the intracorneal inflammation was developed and the untransparent corneas were vascularized. In conclusion, the treatment of UVB-irradiated corneas with trehalose eye drops removed the excessive amount of ROS in the corneal epithelium, leading to the suppression of oxidative stress and favorable corneal healing. The 6% trehalose showed a higher intensive antioxidant effect.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30207 - Ophthalmology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Oxidative Medicine and Cellular Longevity

  • ISSN

    1942-0900

  • e-ISSN

  • Volume of the periodical

    2019

  • Issue of the periodical within the volume

    sep.

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    1857086

  • UT code for WoS article

    000488493500001

  • EID of the result in the Scopus database

    2-s2.0-85072948596