Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00517912" target="_blank" >RIV/68378041:_____/19:00517912 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/19:10396206 RIV/00216208:11110/19:10396206 RIV/00669806:_____/19:10396206 RIV/00064165:_____/19:10396206

Result on the web

<a href="https://www.nature.com/articles/s41416-019-0525-3" target="_blank" >https://www.nature.com/articles/s41416-019-0525-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41416-019-0525-3" target="_blank" >10.1038/s41416-019-0525-3</a>

Result language

angličtina

Original language name

Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis

Original language description

BACKGROUND: Telomeres, repetitive DNA capping ends of eukaryotic chromosomes, are important in the maintenance of genomic integrity. Perturbed telomeres are common features of many human malignancies, including colorectal cancer. nnMETHODS: Telomere length (TL), measured by a Monochrome Multiplex Real-Time qPCR, was investigated in tumour tissues, adjacent mucosa, and blood from patients with colorectal cancer with different clinicopathological features and its impact on patient survival. TL was also measured in a limited number of liver metastases, non-cancerous liver tissues or corresponding tissues from the same patients. nnRESULTS: TL in tumour tissues was shorter than in the adjacent mucosa (P< 0.0001). Shorter TL was observed in tumours with lower stage than in those with advanced stages (P = 0.001). TL was shorter in tumours at the proximal than at the distal sites of the colon (P < 0.0001). Shorter TL was also associated with microsatellite instability (P = 0.001) and mucinous tumour histology (P<0.0001). Patients with a smaller TL ratio between tumour tissues and the adjacent mucosa were associated with increased overall survival (P = 0.022). Metastasised tumours had shorter telomeres than the adjacent non-cancerous liver tissues (P = 0.0005). nnCONCLUSIONS: Overall, the results demonstrate differences in TL between tumours and the adjacent mucosa, between tumours located at different sites and association with patient survival.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30101 - Human genetics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

British Journal of Cancer

ISSN

0007-0920

e-ISSN

—

Volume of the periodical

121

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

344-350

UT code for WoS article

000480675100009

EID of the result in the Scopus database

2-s2.0-85069037316