Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00518208" target="_blank" >RIV/68378041:_____/19:00518208 - isvavai.cz</a>
Result on the web
<a href="https://www.hindawi.com/journals/np/2019/6804575/" target="_blank" >https://www.hindawi.com/journals/np/2019/6804575/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2019/6804575" target="_blank" >10.1155/2019/6804575</a>
Alternative languages
Result language
angličtina
Original language name
Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation
Original language description
The perineuronal net (PNN) is a mesh-like proteoglycan structure on the neuronal surface which is involved in regulating plasticity. The PNN regulates plasticity via multiple pathways, one of which is direct regulation of synapses through the control of AMPA receptor mobility. Since neuronal pentraxin 2 (Nptx2) is a known regulator of AMPA receptor mobility and Nptx2 can be removed from the neuronal surface by PNN removal, we investigated whether Nptx2 has a function in the PNN. We found that Nptx2 binds to the glycosaminoglycans hyaluronan and chondroitin sulphate E in the PNN. Furthermore, in primary cortical neuron cultures, the addition of NPTX2 to the culture medium enhances PNN formation during PNN development. These findings suggest Nptx2 as a novel PNN binding protein with a role in the mechanism of PNN formation.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/EF15_003%2F0000419" target="_blank" >EF15_003/0000419: Center of Reconstructive Neuroscience</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neural Plasticity
ISSN
2090-5904
e-ISSN
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Volume of the periodical
2019
Issue of the periodical within the volume
2019
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
6804575
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85074780778