The Extracellular Matrix and Ca2+ Signaling Mechanisms
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00518847" target="_blank" >RIV/68378041:_____/19:00518847 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/19:10396570 RIV/00216208:11140/19:10396570
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/2019/68_161.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/2019/68_161.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934081" target="_blank" >10.33549/physiolres.934081</a>
Alternative languages
Result language
angličtina
Original language name
The Extracellular Matrix and Ca2+ Signaling Mechanisms
Original language description
The extracellular matrix (ECM) consists of proteins, glycosaminoglycans and glycoproteins, that support the dynamic interactions between cells, including intercellular communication, cell attachment, cell differentiation, cell growth and migration. As such, the ECM represents an essential and very sensitive system within the tissue microenvironment that is involved in processes such as tissue regeneration and carcinogenesis. The aim of the present review is to evaluate its diversity through Ca2+ signaling and its role in muscle cell function. Here, we discuss some methodological approaches dissecting Ca2+ handling mechanisms in myogenic and non-myogenic cells, e.g. the importance of Ca2+ and calpains in muscle dystrophy. We also consider the reconstruction of skeletal muscle by colonization of decellularized ECM with muscle-derived cells isolated from skeletal muscle. Therefore, it is necessary to establish new methodological procedures based on Ca2+ signaling in skeletal muscle cells and their effect on ECM homeostasis, allowing the monitoring of skeletal muscle reconstruction and organ repair.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/GA15-09161S" target="_blank" >GA15-09161S: Muscle remodelling on the basis of extracellular matrix seeded with functionally characterized cells.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
68
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
10
Pages from-to
161-170
UT code for WoS article
000465948800004
EID of the result in the Scopus database
2-s2.0-85065485837