The role of dispersion medium on nanoparticle aggregation and size in biological systems
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00560381" target="_blank" >RIV/68378041:_____/20:00560381 - isvavai.cz</a>
Result on the web
<a href="https://www.confer.cz/nanocon/2019/95-the-role-of-dispersion-medium-on-nanoparticle-aggregation-and-size-in-biological-systems" target="_blank" >https://www.confer.cz/nanocon/2019/95-the-role-of-dispersion-medium-on-nanoparticle-aggregation-and-size-in-biological-systems</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.37904/nanocon.2019.8704" target="_blank" >10.37904/nanocon.2019.8704</a>
Alternative languages
Result language
angličtina
Original language name
The role of dispersion medium on nanoparticle aggregation and size in biological systems
Original language description
The use of nanomaterials (NMs) in different areas has been rising for more than a decade. Along with this growth, there is visible development of different testing tools and approaches for measuring the actual size of nanomaterials in biological systems. Test conditions during in vitro toxicological assays are different from the standard conditions under which nanomaterials are characterized and careful evaluation of results is needed. The unique properties and range variety of NMs require the close look how the NMs behave in different dispersion medium over time. In this study we present the results of five types of well-characterized NMs (TiO2: NM-101 and NM-103, SiO2: NM-200, Ag: NM-300K and NM-302) of specific size and shape. The hydrodynamic size and Zeta potentials in suspensions were measured using a dynamic light scattering technique (DLS) (Zetasizer Nano ZS, Malvern, UK). The DLS method is suitable for spherical particles, nevertheless, all samples were measured in order to obtain a rough insight into agglomerate formation in the medium. NM300, NM302, and NM200 aggregated rapidly in the media, thus the cells would be most likely exposed to settled big aggregates then small clusters or individual particles. More stable NMs (NM100 and NM103) showed slight grow along with cultivation time or concentration corresponding to cluster formation. Cells exposed to those NMs would be in contact with small clusters and aggregates of NMs. Measured zeta potentials fluctuated around the stability limit corresponding to observed aggregation.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
<a href="/en/project/LO1508" target="_blank" >LO1508: Genomics and proteomics in the study of mechanisms of biological effects of produced nanoparticles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Nanocon 2019 : Proceedings of the International Conference on Nanomaterials - Research & Application /11./
ISBN
978-80-87294-95-6
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
508-513
Publisher name
Tanger Ltd.
Place of publication
Ostrava
Event location
Brno
Event date
Oct 16, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000664115400087