Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00552873" target="_blank" >RIV/68378041:_____/21:00552873 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/21:00555019
Result on the web
<a href="https://www.nature.com/articles/s41556-021-00746-2" target="_blank" >https://www.nature.com/articles/s41556-021-00746-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41556-021-00746-2" target="_blank" >10.1038/s41556-021-00746-2</a>

Result language
angličtina
Original language name
Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs
Original language description
A set of three papers reports that the piRNA pathway is essential for mammalian female fertility based on genetic perturbation experiments performed in golden hamsters.nnPIWI-interacting RNAs (piRNAs) support the germline by suppressing retrotransposons. Studies of the pathway in mice have strongly shaped the view that mammalian piRNAs are essential for male but not for female fertility. Here, we report that the role of the piRNA pathway substantially differs in golden hamsters (Mesocricetus auratus), the piRNA pathway setup of which more closely resembles that of other mammals, including humans. The loss of the Mov10l1 RNA helicase-an essential piRNA biogenesis factor-leads to striking phenotypes in both sexes. In contrast to mice, female Mov10l1(-/-) hamsters are sterile because their oocytes do not sustain zygotic development. Furthermore, Mov10l1(-/-) male hamsters have impaired establishment of spermatogonia accompanied by transcriptome dysregulation and an expression surge of a young retrotransposon subfamily. Our results show that the mammalian piRNA pathway has essential roles in both sexes and its adaptive nature allows it to manage emerging genomic threats and acquire new critical roles in the germline.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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