Intracellular localization and routing of miRNA and RNAi pathway components

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00387844" target="_blank" >RIV/68378050:_____/12:00387844 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.2174/156802612798919132" target="_blank" >http://dx.doi.org/10.2174/156802612798919132</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/156802612798919132" target="_blank" >10.2174/156802612798919132</a>

Result language

angličtina

Original language name

Intracellular localization and routing of miRNA and RNAi pathway components

Original language description

Several different pathways, generally termed RNA silencing pathways, utilize small RNA molecules guiding sequence-specific silencing effects of ribonucleoprotein effector complexes, traditionally termed RNA-induced silencing complex (RISC). Three RNA silencing pathways were recognized in mammalian cells: RNA interference (RNAi), where short RNAs produced from long double-stranded RNA guide cleavage of cognate mRNAs, microRNA (miRNA) pathway, where endogenously-encoded miRNAs typically induce translational repression, and piRNA pathway, where piRNAs (PIWI-associated RNAs) guide repression of repetitive sequences in the germline. Originally, RNAi and miRNA pathways were thought to act in the cytoplasm, however, there is a growing body of evidence that these pathways also have a nuclear component. This text reviews the current evidence concerning nuclear localization and function of miRNA and RNAi pathway components. We provide evidence that TRBP, Dicer and AGO2, proteins found in the RIS

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA204%2F09%2F0085" target="_blank" >GA204/09/0085: RNA silencing and long dsRNA in mammalian cells</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Topics in Medicinal Chemistry

ISSN

1568-0266

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

79-88

UT code for WoS article

000300408700003

EID of the result in the Scopus database

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