RNAi and miRNA pathways in nematodes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523491" target="_blank" >RIV/68378050:_____/19:00523491 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
RNAi and miRNA pathways in nematodes
Original language description
RNA silencing denotes sequence-specific repression mediated by small RNAs. In metazoa, there are two mechanistically closely related pathways: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression and has been implicated in many biological processes. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements. This review is summarizing information about RNAi and miRNA pathways in the phylum Nematoda. Research on miRNA and RNAi pathway in the phylum Nematoda has been primarily using Caenorhabditis elegans model system and related species. In fact, miRNA and RNAi pathways were both discovered in this model system. Studies in Caenorhabditis elegans revealed highly complex organization of small RNA pathways despite there is just a single Dicer gene. The complexity of small RNA pathways in Caenorhabditis elegans stems from a large number of Argonaute proteins and three RNA-dependent RNA polymerases, which establish an intricate system of primary and secondary small RNAs with different biological functions in the cytoplasm and nucleus. This review focuses on the miRNA pathway and pathways initiated by long dsRNA. The first part introduces the key molecular players of RNA silencing in nematodes. The second summarizes miRNA and dsRNA-induced mechanisms, in this case RNAi (exogenous = exo-RNAi and endogenous = endo-RNAi) and adenosine deamination (nematodes do not have the interferon system like vertebrate groups).
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
<a href="/en/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: National infrastructure for chemical biology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Introduction to RNAi and miRNA pathways
ISBN
978-80-246-4372-4
Number of pages of the result
26
Pages from-to
1-339
Number of pages of the book
339
Publisher name
Karolinum
Place of publication
Praha
UT code for WoS chapter
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