RNAi and miRNA pathways in arthropods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523489" target="_blank" >RIV/68378050:_____/19:00523489 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
RNAi and miRNA pathways in arthropods
Original language description
RNA silencing denotes sequence-specific repression mediated by small RNAs. In vertebrates, there are two closely related pathways, which share several protein factors: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression and has been implicated in many biological processes. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements. While Arthropoda are an extremely large and diverse phylum, research on microRNA (miRNA) and RNA interference (RNAi) pathway in this phylum primarily used the Drosophila melanogaster model system and related species. Notably, both pathways are genetically separated, they utilize dedicated Dicer proteins to produce miRNAs and small interfering RNAs (siRNAs), which are sorted onto different Argonaute effector proteins. This review focuses on the miRNA pathway and pathways initiated by long dsRNA in arthropods. The first part introduces the key molecular players of RNA silencing. The second discussed biological roles of miRNA and dsRNA-induced pathways in Arthropods.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
<a href="/en/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: National infrastructure for chemical biology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Introduction to RNAi and miRNA pathways
ISBN
978-80-246-4372-4
Number of pages of the result
34
Pages from-to
1-339
Number of pages of the book
339
Publisher name
Karolinum
Place of publication
Praha
UT code for WoS chapter
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