Extracellular small RNAs and their transfer between species and kingdoms
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523495" target="_blank" >RIV/68378050:_____/19:00523495 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Extracellular small RNAs and their transfer between species and kingdoms
Original language description
RNA silencing is a common term for mechanisms where small RNAs guide repression of other RNAs (mRNAs, retrotransposon RNAs, viral RNAs) in a sequence-specific manner. RNA silencing exists among eukaryotic organisms where the core mechanisms evolved into many variants with different biological functions. The two most common RNA silencing pathways are microRNA (miRNA) and RNA interference (RNAi). While the miRNA pathway serves for negative regulation of endogenous genes, RNAi pathway usually functions as a form of protection against parasitic sequences although it also target endogenous genes in some cases. Notably, RNA silencing does not operate in a cell-autonomous manner. In a number of cases, small RNAs were detected in extracellular environment and were observed to pass through cells and oven be transferred between organisms. This review provides an overview “mobile” small RNAs, with a particular focus on miRNAs and short interfering RNAs (siRNA) of the RNAi pathways, which exert their effects in different species than they originate from.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
<a href="/en/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: National infrastructure for chemical biology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Introduction to RNAi and miRNA pathways
ISBN
978-80-246-4372-4
Number of pages of the result
8
Pages from-to
1-339
Number of pages of the book
339
Publisher name
Karolinum
Place of publication
Praha
UT code for WoS chapter
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