Glyphosate Interaction with eEF1 alpha 1 Indicates Altered Protein Synthesis: Evidence for Reduced Spermatogenesis and Cytostatic Effect

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00553278" target="_blank" >RIV/68378041:_____/21:00553278 - isvavai.cz</a>
Alternative codes found
RIV/00027006:_____/21:10150360 RIV/68407700:21720/21:00355571 RIV/62157124:16170/21:43879822 RIV/61989592:15110/21:73607432
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsomega.1c00449" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.1c00449</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.1c00449" target="_blank" >10.1021/acsomega.1c00449</a>

Result language
angličtina
Original language name
Glyphosate Interaction with eEF1 alpha 1 Indicates Altered Protein Synthesis: Evidence for Reduced Spermatogenesis and Cytostatic Effect
Original language description
The broad-spectrum herbicide, glyphosate, is considered safe for animals because it selectively affects the shikimate pathway that is specific to plants and microorganisms. We sought a previously unknown mechanism to explain the concerns that glyphosate exposure can negatively affect animals, including humans. Computer modeling showed a probable interaction between glyphosate and eukaryotic translation elongation factor 1 subunit alpha 1 (eEF1 alpha 1), which was confirmed by microcalorimetry. Only restricted, nondisrupted spermatogenesis in rats was observed after chronic glyphosate treatments (0.7 and 7 mg/L). Cytostatic and antiproliferative effects of glyphosate in GC-1 and SUP-B15 cells were indicated. Meta-analysis of public health data suggested a possible effect of glyphosate use on sperm count. The in silico, in vitro, and in vivo experimental results as well as the metastatistics indicate side effects of chronic glyphosate exposure. Together, these findings indicate that glyphosate delays protein synthesis through an interaction with eEF1 alpha 1, thereby suppressing spermatogenesis and cell growth.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)