TElomeric repeat-containing RNA (TERRA): Physiological functions and relevance in cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00568543" target="_blank" >RIV/68378041:_____/22:00568543 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/22:10446708 RIV/00216208:11110/22:10446708 RIV/00064190:_____/22:N0000041
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fonc.2022.913314/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fonc.2022.913314/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fonc.2022.913314" target="_blank" >10.3389/fonc.2022.913314</a>
Alternative languages
Result language
angličtina
Original language name
TElomeric repeat-containing RNA (TERRA): Physiological functions and relevance in cancer
Original language description
Telomeres are complex protective structures located at the ends of linear eukaryotic chromosomes. Their purpose is to prevent genomic instability. Research progress in telomere biology during the past decades has identified a network of telomeric transcripts of which the best-studied is TElomeric Repeat-containing RNA (TERRA). TERRA was shown to be important not only for the preservation of telomere homeostasis and genomic stability but also for the expression of hundreds of genes across the human genome. These findings added a new level of complexity to telomere biology. Herein we provide insights on the telomere transcriptome, its relevance for proper telomere function, and its implications in human pathology. We also discuss possible clinical opportunities of exosomal telomere transcripts detection as a biomarker in cancer precision medicine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Oncology
ISSN
2234-943X
e-ISSN
2234-943X
Volume of the periodical
12
Issue of the periodical within the volume
aug.
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
913314
UT code for WoS article
000841193100001
EID of the result in the Scopus database
2-s2.0-85136202464