Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F24%3A00587724" target="_blank" >RIV/68378041:_____/24:00587724 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/24:10481788 RIV/00216208:11140/24:10481788 RIV/00216208:11110/24:10481788 RIV/00216208:11120/24:43927314 and 4 more

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2405844024095562?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2405844024095562?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.heliyon.2024.e33525" target="_blank" >10.1016/j.heliyon.2024.e33525</a>

Result language

angličtina

Original language name

Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma

Original language description

Impaired telomere length (TL) maintenance in ovarian tissue may play a pivotal role in the onset of epithelial ovarian cancer (OvC). TL in either target or surrogate tissue (blood) is currently being investigated for use as a predictor in anti-OvC therapy or as a biomarker of the disease progression, respectively. There is currently an urgent need for an appropriate approach to chemotherapy response prediction.nWe performed a monochrome multiplex qPCR measurement of TL in peripheral blood leukocytes (PBL) and tumor tissues of 209 OvC patients. The methylation status and gene expression of the shelterin complex and telomerase catalytic subunit (hTERT) were determined within tumor tissues by High-Throughput DNA methylation profiling and RNA sequencing (RNA-Seq) analysis, respectively. The patients sensitive to cancer treatment (n = 46) had shorter telomeres in PBL compared to treatment-resistant patients (n = 93, P = 0.037). In the patients with a different therapy response, transcriptomic analysis showed alterations in the peroxisome proliferator-activated receptor (PPAR) signaling pathway (q = 0.001). Moreover, tumor TL shorter than the median corresponded to better overall survival (OS) (P = 0.006). TPP1 gene expression was positively associated with TL in tumor tissue (P = 0.026).nTL measured in PBL could serve as a marker of platinum therapy response in OvC patients. Additionally, TL determined in tumor tissue provides information on OvC patients' OS.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Heliyon

ISSN

2405-8440

e-ISSN

2405-8440

Volume of the periodical

10

Issue of the periodical within the volume

13

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

e33525

UT code for WoS article

001265876200001

EID of the result in the Scopus database

2-s2.0-85197220478