Neuronal maturation and axon regeneration: unfixing circuitry to enable repair
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F24%3A00598841" target="_blank" >RIV/68378041:_____/24:00598841 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41583-024-00849-3" target="_blank" >https://www.nature.com/articles/s41583-024-00849-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41583-024-00849-3" target="_blank" >10.1038/s41583-024-00849-3</a>
Alternative languages
Result language
angličtina
Original language name
Neuronal maturation and axon regeneration: unfixing circuitry to enable repair
Original language description
Mammalian neurons lose the ability to regenerate their central nervous system axons as they mature during embryonic or early postnatal development. Neuronal maturation requires a transformation from a situation in which neuronal components grow and assemble to one in which these components are fixed and involved in the machinery for effective information transmission and computation. To regenerate after injury, neurons need to overcome this fixed state to reactivate their growth programme. A variety of intracellular processes involved in initiating or sustaining neuronal maturation, including the regulation of gene expression, cytoskeletal restructuring and shifts in intracellular trafficking, have been shown to prevent axon regeneration. Understanding these processes will contribute to the identification of targets to promote repair after injury or disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Reviews Neuroscience
ISSN
1471-003X
e-ISSN
1471-0048
Volume of the periodical
25
Issue of the periodical within the volume
10
Country of publishing house
DE - GERMANY
Number of pages
19
Pages from-to
649-667
UT code for WoS article
001295024600001
EID of the result in the Scopus database
2-s2.0-85201608153