Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F01%3A23010356" target="_blank" >RIV/68378050:_____/01:23010356 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection.

Original language description

Generation of free radicals is often associated with the induction of apoptosis. Exposure of Jurkat cells to alpha-tocopheryl succinate (alpha-TOS), hydrogen peroxide (HP), anti-Fas IgM or TRAIL led to apoptosis. The reduced form of coenzyme Q suppressedcell death due to the chemical agents. However, coenzyme did not block apoptosis induced by anti-Fas IgM or TRAIL. Ubiquinol-10 inhibited ROS generation in cells exposed to alpha-TOS, and mitochondrially-targeted coenzyme Q analogue blocked apoptosis induced by alpha-TOS.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA301%2F99%2F0350" target="_blank" >GA301/99/0350: Screening for and characterization of novel, apoptosis inducing surface molecules of human hematopoietic cells</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FEBS Letters

ISSN

0014-5793

e-ISSN

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Volume of the periodical

503

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

46-50

UT code for WoS article

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EID of the result in the Scopus database

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