The 3´ untranslated region of the chicken c-src protooncogene modulates gene expression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F03%3A00108995" target="_blank" >RIV/68378050:_____/03:00108995 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/03:00191522
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The 3´ untranslated region of the chicken c-src protooncogene modulates gene expression
Original language description
The chicken c-src 3´UTR effects on gene expression have been explored. The c-src 3´UTR decreased the in vivo tumorigenic potential of the src-activated mutants in chickens. This corresponds with the finding that the c-src 3´UTR reduced the Src protein and src mRNA levels and luciferase activity in vitro. Our results suggest that the chicken c-src 3´UTR plays a role in the negative control of gene expression, either transcriptionally or posttranscriptionally
Czech name
3´-netranslatovaná oblast kuřecího protoonkogenu c-src moduluje genovou expresi
Czech description
Byly studovány účinky kuřecí c-src 3´UTR na genovou expresi. c-src 3´UTR snižovala in vivo tumorigenní potenciál mutant s aktivovaným src v kuřatech. To je v souladu s poznatkem, že c-src 3´UTR snižovala hladinu proteinu Src a src mRNA a luciferázovou aktivitu in vitro. Z našich výsledků vyplývá, že kuřecí c-src 3´UTR hraje roli v negativní regulaci genové exprese, a to transkripčně či posttranskripčně
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Folia Biologica
ISSN
0015-5500
e-ISSN
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Volume of the periodical
49
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
12
Pages from-to
51-62
UT code for WoS article
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EID of the result in the Scopus database
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