Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F07%3A00091832" target="_blank" >RIV/68378050:_____/07:00091832 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors

Original language description

To investigate the viral features of long-term nonprogressive HIV-1 infection and the selection of viral genomes, we studied serial complete HIV-1 sequences obtained from a mother-child pair, both long-term nonprogressors. Analysis of four genomic sequences demonstrated that all viral genes were intact, lacking major deletions or premature stop codons to easily explain the slow disease progression. These data suggest that viral attenuation, if present, was caused by subtle sequence variations or virus-host interactions. We demonstrated that the daughter's strains were most likely subjected to immunoselection or immunoediting according to the presence of novel MHC class I alleles that differed between mother and daughter. An analysis of nef-specific cytotoxic T-lymphocyte responses in the child, whose HIV-1 nef sequence differed from the maternal nef, supported this interpretation.

Czech name

Genová analýza HIV-1 virových kmenů izolovaných od matky a jejího dítěte, dlouhodobě non-progresorů

Czech description

Při dlouhotrvající infekci virem HIV-1 bez projevu onemocnění byly u matky a jejího dítěte zjišťovány rozdíly v genomu infikujících virů. Bylo zjištěno, že u prověřovaných kmenů nedošlo ke změnám, které by oslabily jejich účinnost a že atenuace onemocnění je způsobena pravděpodobně interakcí virů a imunitního systemu hostitele.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Aids Research and Human Retroviruses

ISSN

0889-2229

e-ISSN

—

Volume of the periodical

23

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

309-315

UT code for WoS article

—

EID of the result in the Scopus database

—