Heterochromatin marks HP1gamma, HP1alpha and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00347140" target="_blank" >RIV/68378050:_____/11:00347140 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/j.1365-2605.2010.01096.x" target="_blank" >http://dx.doi.org/10.1111/j.1365-2605.2010.01096.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1365-2605.2010.01096.x" target="_blank" >10.1111/j.1365-2605.2010.01096.x</a>

Result language

angličtina

Original language name

Heterochromatin marks HP1gamma, HP1alpha and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours

Original language description

Heterochromatinization has been implicated in fundamental biological and pathological processes including differentiation, senescence, ageing and tumorigenesis; however, little is known about its regulation and roles in human cells and tissues in vivo. Here, we show distinct cell-type- and cancer-stage-associated patterns of key heterochromatin marks: histone H3 trimethylated at lysine 9 (H3K9me3) and heterochromatic adaptor proteins HP1? and HP1?, compared with the ?H2AX marker of endogenously activated DNA damage response (DDR) and proliferation markers in normal human foetal and adult testes, pre-invasive carcinoma in situ (CIS) lesions and a series of overt germ cell tumours, including seminomas, embryonal carcinomas and teratomas. Among striking findings were high levels of HP1? in foetal gonocytes, CIS and seminomas; enhanced multimarker heterochromatinization without DDR activation in CIS; and enhanced HP1? in teratoma structures with epithelial and neuronal differentiation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA301%2F08%2F0353" target="_blank" >GA301/08/0353: Protein modifications in DNA damage signalling: Mechanisms and cancer relevance</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Andrology

ISSN

0105-6263

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

"e103"-"e113"

UT code for WoS article

000293174100013

EID of the result in the Scopus database

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